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Relevant clinical diseases Neurodegenerative diseases Generally, neurodegenerative diseases (NDDs) exhibit multiple and common pathological effects, including defects in mitochondria, protein quality control, and the autophagic-lysosomal network, which lead to the aggregation and accumulation of misfolded proteins [173, 174]

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Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression: An Evidence Report for a Clinical Practice Guideline From the American College of Physicians

3) is the maintenance of tissue homoeostasis at all the levels of CNS organisation, from molecular (ions, metabolites, and neurotransmitters, etc.), to network (regulation of synaptic connectivity), to organ (formation and maintenance of bloodbrain barrier and glymphatic clearance system) and systemic (chemosensing blood oxygen, Na + , CO 2 or glucose)

Individual results vary based on starting condition, product quality, protocol consistency, and other factors

A patient asking for help with disrupted sleep and circadian rhythm is evaluated differently from a patient interested in cellular-aging markers as part of a broader longevity strategy